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dc.creatorGassen, Jeffrey
dc.creatorWhite, Jordon D.
dc.creatorPeterman, Julia L.
dc.creatorMengelkoch, Summer
dc.creatorLeyva, Randi P. Proffitt
dc.creatorProkosch, Marjorie L.
dc.creatorEimerbrink, Micah J.
dc.creatorBrice, Kelly
dc.creatorCheek, Dennis J.
dc.creatorBoehm, Gary W.
dc.creatorHill, Sarah E.
dc.description.abstractEarly life stress increases one's risk for health problems later in life, and many studies find that these effects are sex-differentiated. Here, we examined relationships between multiple sources of early life stress and adult immune function in humans across several functional assays. Adult participants provided retrospective information about their childhood (a) socioeconomic status, (b) household unpredictability, and (c) exposure to adverse experiences. Participants' peripheral blood mononuclear cells (PBMCs) were then isolated for use in functional assays of immune performance: (a) tumor cell lysis by natural killer cells, (b) phagocytosis of Escherichia coli bioparticles, and (c) mitogen-induced leukocyte proliferation and cytokine release. In men, lower childhood socioeconomic status predicted decrements in immunological performance across functional assays, along with greater spontaneous cytokine release from PBMCs. These changes co-occurred with elevations in plasma testosterone levels. Similar effects were not observed for other sources of stress, nor were they found in women (with the exception of spontaneous cytokine release). These findings provide evidence that low childhood socioeconomic status has a lasting negative impact on multiple aspects of immune function, particularly in men.en_US
dc.sourceScientific Reports
dc.subjectEvolutionary developmental biologyen_US
dc.subjectHuman behaviouren_US
dc.subjectRisk factorsen_US
dc.titleSex differences in the impact of childhood socioeconomic status on immune functionen_US
dc.rights.holder2021 Authors
dc.rights.licenseCC BY 4.0
local.collegeCollege of Science and Engineering
local.collegeHarris College of Nursing and Health Sciences
local.personsPeterman (PSYC), Mengelkoch (PSYC), Layva (PSYC), Eimerbrink (PSYC), Brice (PSYC), Cheek (NURS), Boehm (PSYC), Hill (PSYC)

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