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dc.creatorNumai S.
dc.creatorYoto R.
dc.creatorKimura M.
dc.creatorSimanek E. E.
dc.creatorKitano Y.
dc.date.accessioned2023-10-20T16:07:08Z
dc.date.available2023-10-20T16:07:08Z
dc.date.issued2023
dc.identifier.urihttps://doi.org/10.3390/molecules28010131
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/61276
dc.description.abstractDendrimers are attractive macromolecules for a broad range of applications owing to their well-defined shapes and dimensions, highly branched and globular architectures, and opportunities for exploiting multivalency. Triazine dendrimers in particular offer advantages such as ease of synthesis, stability, well-defined spherical structure, multivalency, potential to achieve acceptable drug loadings, and low polydispersity. In this study, the potential utility of alkyne-azide "click" cycloadditions of first-, second-, and third-generation triazine dendrimers containing three or six alkynyl groups with benzyl azide was examined using copper catalysts. "Click-and-grow" and "grow-then-click" strategies were employed. For the first- and second- generation dendrimers, the desired triazole derivatives were obtained in high yields and purified by simple reprecipitation without column chromatography; however, some difficulties were observed in the preparation of third-generation dendrimers. The desired reaction proceeded under microwave irradiation as well as with simple heating. This click chemistry can be utilized for various melamine dendrimers that are fabricated with other amine linkers. ¿ 2022 by the authors.
dc.languageen
dc.publisherMDPI
dc.sourceMolecules
dc.subjectclick chemistry
dc.subjectdendrimer
dc.subjectHuisgen cycloaddition
dc.subjecttriazine
dc.titleClick Chemistry of Melamine Dendrimers: Comparison of "Click-and-Grow" and "Grow-Then-Click" Strategies Using a Divergent Route to Diversity
dc.typeArticle
dc.rights.licenseCC BY 4.0
local.collegeCollege of Science and Engineering
local.departmentChemistry and Biochemistry
local.personsSimanek (CHEM)


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