| dc.description.abstract | Reward loss and the accompanying emotional responses have been the subject of extensive research in psychology and neuroscience. The experience of reward loss is associated with a range of negative emotions and stress responses, which have implications for substance use disorders, anxiety disorders, and depression. This investigation employs c-Fos as a marker of neuronal activation to examine the early responses of the brain to reward loss. A Pavlovian successive negative contract (pSNC) paradigm was implemented to induce anticipatory behavior and free choice influenced by reward loss. The results of the pSNC paradigm demonstrated altered neuronal patterns and significant correlations between brain regions in response to reward downshift. These findings contribute to the neural circuity underlying reward loss and the potential engagement of multiple brain areas in reward processing and emotional regulation. | |
