The Effects of High-Fructose Corn Syrup on Weight Gain and Spatial Memory

Abstract

High-fructose corn syrup (HFCS) has become an increasingly used substitute for sugar in people's diets worldwide. Despite its growing prevalence, HFCS is linked to many detrimental conditions such as obesity, hypertension, type 2 diabetes, liver disease and hypertension. HFCS has also been linked to insulin resistance. Because neural insulin signaling facilitates hippocampal-dependent memory, we hypothesized that a diet high in HFCS would impair hippocampal-dependent learning and memory. In this article, the effects of high-fructose corn syrup on spatial learning and memory are investigated using C57BL/6 mice and water radial arm maze (WRAM).