Characterization of the 5xFAD Transgenic Mouse and the Effectiveness of Hydroxylpyclen in the Disaggregation of AB Plaques and Restoration of Cognitive Function in Alzheimer's DiseaseShow full item record
Title | Characterization of the 5xFAD Transgenic Mouse and the Effectiveness of Hydroxylpyclen in the Disaggregation of AB Plaques and Restoration of Cognitive Function in Alzheimer's Disease |
---|---|
Author | Gurney, Troy |
Date | 2015 |
Abstract | Alzheimer's disease (AD), a neurodegenerative disorder with no known cure or treatment, is the most prevalent form of age-related dementia. As both the rate and total number of those diagnosed continues to increase, AD has become a global concern. The transgenic 5xFAD mouse model expresses familial AD due to mutations in both amyloid-beta precursor protein (APP) and presenilin-1 (PS1). The AD hallmarks exhibited include amyloid-beta (A-beta) plaque deposition around 2 months of age and hippocampus synaptic dysfunction around 9 months of age, which result in severe accelerated cognitive impairment. Through contextual fear conditioning (CFC) and radial arm water maze paradigms, as well as Thioflavin-S A-beta plaque staining, this study characterized in our own lab the AD hallmarks that have been previously demonstrated in the 5xFAD mouse model. Copper-chelation, antioxidants, and reactive oxygen species (ROS) reduction have shown promise individually as potential treatment options for AD. The novel hydroxylpyclen from Green Research Laboratory has been previously shown to exhibit all of these capabilities, while not detrimentally interfering with cell processes or viability. Therefore, after characterization, this study explored hydroxylpyclen as a potential treatment in 9 month old, transgenic positive 5xFAD mice. By injecting mice daily for 28 days with 222mg/kg hydroxylpyclen, our lab has shown promise for an AD treatment option by producing improvement in context-dependent cognitive behavior as compared to controls in CFC, as well as reductions in A-beta hippocampal plaque and ROS species. |
Link | https://repository.tcu.edu/handle/116099117/10338 |
Department | Biology |
Advisor | Chumley, Michael |
Additional Date(s) | 2015-05-01 |
Files in this item
This item appears in the following Collection(s)
- Undergraduate Honors Papers [1362]
Related items
Showing a few items related by title, author, creator and subject.
-
The Regulation of Nur77 in Response to Inflammation, Amyloid-Beta, and Exercise in an LPS-Induced Alzheimer's Disease Model
Hayes, Hailey (2015)According to the Alzheimer's Association, Alzheimer's Disease (AD) is the sixth leading cause of death in the United States, and is the only leading cause of death that cannot be prevented or slowed. Nur77 is a member of ... -
Sex-mediated differences in the effects of early-life stress on Alzheimer's pathology in C57BL/6 mice
Moore, Haley (2018)Alzheimer's Disease (AD) is the most common form of dementia and is currently estimated to affect over 5 million Americans. There is no treatment for AD, and the incidence is expected to increase as our population grows ... -
Effects Of Chronic Mild Sleep Restriction Following Repeated Endotoxin Exposure On Alzheimer's Disease Pathology In Healthy Wild Type Mice
Hardiman, Brooke (2018)An estimated 46.8 million people are living with dementia, and those numbers are expected to rise to 74.7 million by 2030. Alzheimer's disease (AD) is the most common underlying cause of dementia and accounts for up to 70% ...
© TCU Library 2015 | Contact Special Collections |
HTML Sitemap