Characterization of the 5xFAD Transgenic Mouse and the Effectiveness of Hydroxylpyclen in the Disaggregation of AB Plaques and Restoration of Cognitive Function in Alzheimer's DiseaseShow full item record
|Title||Characterization of the 5xFAD Transgenic Mouse and the Effectiveness of Hydroxylpyclen in the Disaggregation of AB Plaques and Restoration of Cognitive Function in Alzheimer's Disease|
|Abstract||Alzheimer’s disease (AD), a neurodegenerative disorder with no known cure or treatment, is the most prevalent form of age-related dementia. As both the rate and total number of those diagnosed continues to increase, AD has become a global concern. The transgenic 5xFAD mouse model expresses familial AD due to mutations in both amyloid-beta precursor protein (APP) and presenilin-1 (PS1). The AD hallmarks exhibited include amyloid-beta (Aβ) plaque deposition around 2 months of age and hippocampus synaptic dysfunction around 9 months of age, which result in severe accelerated cognitive impairment. Through contextual fear conditioning (CFC) and radial arm water maze paradigms, as well as Thioflavin-S Aβ plaque staining, this study characterized in our own lab the AD hallmarks that have been previously demonstrated in the 5xFAD mouse model. Copper-chelation, antioxidants, and reactive oxygen species (ROS) reduction have shown promise individually as potential treatment options for AD. The novel hydroxylpyclen from Green Research Laboratory has been previously shown to exhibit all of these capabilities, while not detrimentally interfering with cell processes or viability. Therefore, after characterization, this study explored hydroxylpyclen as a potential treatment in 9 month old, transgenic positive 5xFAD mice. By injecting mice daily for 28 days with 222mg/kg hydroxylpyclen, our lab has shown promise for an AD treatment option by producing improvement in context-dependent cognitive behavior as compared to controls in CFC, as well as reductions in Aβ hippocampal plaque and ROS species.|
Familial Alzheimer's Disease
Contextual Fear Conditioning
Radial Arm Water Maze
This item appears in the following Collection(s)
- Honors Projects 
Showing a few items related by title, author, creator and subject.
The Regulation of Nur77 in Response to Inflammation, Amyloid-Beta, and Exercise in an LPS-Induced Alzheimer's Disease Model Hayes, HaileyAccording to the Alzheimer's Association, Alzheimer’s Disease (AD) is the sixth leading cause of death in the United States, and is the only leading cause of death that cannot be prevented or slowed. Nur77 is a member ...
ENHANCING BLOOD BRAIN BARRIER PERMEABILITY OF THERAPUETIC AGENTS FOR ALZHEIMER?S DISEASE BY ADDING GLUCOSE. Canipe, Matthew (2016-05-19)The Green Research Group has previously synthesized molecules that are capable of combating the hallmarks of Alzheimer?s disease and preventing and reversing amyloid beta aggregate formation. While preliminary studies show ...
A potential role for LPS-induced inflammation in the induction of Alzheimer's disease-related pathology and cognitive deficits [electronic resource] / Kahn, Marielle Suzanne ([Fort Worth, Tex.] : Texas Christian University,, 2011)Alzheimer's disease (AD) is characterized by neuronal cell death in regions of the adult brain, including the hippocampus, due to formation of amyloid-beta plaques and neurofibrillary tangles. Inflammation has been implicated ...