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dc.contributor.authorRuff, Charlie
dc.date2015-05-01
dc.date.accessioned2016-02-19T15:38:38Z
dc.date.available2016-02-19T15:38:38Z
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/10427
dc.description.abstractBODIPY dyes are versatile sensors because of their many desirable photophysical properties. These dyes have been shown to be viable probes for detecting amyloid β peptides, while showing significant advantages over currently utilized dye-binding assays. Most of the research and development of these dyes has been done on symmetric compounds, and current syntheses of non-symmetric dyes are neither facile nor efficient. Our research has examined ways to synthesize non-symmetric BODIPY dyes more efficiently using a solvent-free, one-pot synthetic approach. By grinding a pyrrole and a carbonyl-containing pyrrole in the presence of a base, followed by the addition of boron trifluoride, we have synthesized non-symmetric BODIPY dyes in a more expeditious manner. Our current synthetic methods appear to be applicable to a variety of structurally and functionally diverse BODIPY dyes, although the overall efficiency still needs improvements. Based on the initial success, it is anticipated that a facile, efficient and economical synthetic approach toward non-symmetric BODIPY dyes will be achieved in the near future.
dc.subjectBODIPY
dc.subjectdyes
dc.subjectsynthesis
dc.subjectnon-symmetric
dc.subjectsensors
dc.subjectdetection
dc.subjectamyloids
dc.subjectplaques
dc.subjectbeta
dc.subjectAlzheimers
dc.subjectfluorescent
dc.subjectboron
dc.subjectapproaches
dc.subjectsymmetric
dc.titleSYNTHETIC APPROACHES TO NON-SYMMETRIC BODIPY DYES: WORKING TOWARD SMALL MOLECULAR SENSORS FOR DETECTION OF AMYLOIDSen_US
etd.degree.departmentBiochemistry


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