Phenanthridone Alkaloids via Functionalization of 2-Benzyl- 6(5H)-PhenanthridinoneShow full item record
|Title||Phenanthridone Alkaloids via Functionalization of 2-Benzyl- 6(5H)-Phenanthridinone|
|Abstract||Phenanthridone alkaloids, derived from the Amaryllidiceae family of tropical plants, are a group of natural products that have been shown to exhibit biological activity. In recent decades, this group of alkaloids has sparked interest due to their antibiotic, anticancer, and immunosuppressant properties. Because of their limited natural availability, pharmaceutically-active compounds require laboratory syntheses to provide sufficient quantities for testing. Previous work in this laboratory has provided a general method for constructing the phenanthridinone skeleton from homophthalic acid in high yields. In this research project, our work involves the reproduction of these results as well as establishing a general method for functionalization of the non-conjugated alkene in the phenanthridinone skeleton. This research provides the basis for future syntheses of complex alkaloids that show promise in the development of pharmaceutically-active compounds.|
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Transformations of isocarbostyrils for the synthesis of isoquinoline alkaloids and the related analogues [electronic resource] / Huang, Yijun ([Fort Worth, Tex.] : Texas Christian University,, 2008)A practical method for the synthesis of an isoquinoline alkaloid 6,7-dimethoxy-2-methylisoquinoline-1,3,4(2H)-trione and its analogues has been demonstrated. Two new methods for synthesizing substituted phthalonimides from ...
Synthetic approaches to the skeleton of crinine-type alkaloids from isoquinoline and the total synthesis of (?)-crinine [electronic resource] / Bian, Zhiguo ([Fort Worth, Tex.] : Texas Christian University,, 2010)The crinine-type alkaloids, which have the 5,10b-ethanophenanthridine skeleton as the core structure, represent an important sub-class of the family of Amaryllidaceae alkaloids. Considering the obvious structural relationship ...
Total synthesis of the crinane-type Amaryllidaceae alkaloids (+)-maritidine and (+)-oxomaritidine [electronic resource] / Ding, Lixin ([Fort Worth, Tex.] : Texas Christian University,, 2010)The crinane-type alkaloids are characterized by the presence of the 5,10b-ethanophenanthridine skeleton and represent an important subgroup within the large family of Amaryllidaceae alkaloids, many of which exhibit interesting ...