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dc.creatorOliver, Jonathan M.
dc.creatorStoner, Lee
dc.creatorRowlands, David S.
dc.creatorCaldwell, Aaron R.
dc.creatorSanders, Elizabeth
dc.creatorKreutzer, Andreas
dc.creatorMitchell, Joel B.
dc.creatorPurpura, Martin
dc.creatorJäger, Ralf
dc.date.accessioned2017-07-03T16:19:32Z
dc.date.available2017-07-03T16:19:32Z
dc.date.issued2016-08-17
dc.identifier.urihttps://doi.org/10.1155/2016/1089653
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/19947
dc.identifier.urihttps://www.hindawi.com/journals/jnme/2016/1089653/
dc.description.abstractCurcumin, a turmeric extract, may protect against cardiovascular diseases by enhancing endothelial function. In this randomized controlled double-blind parallel prospective study, fifty-nine healthy adults were assigned to placebo, 50mg (50mg), or 200mg (200mg) curcumin, for 8 weeks. The higher curcumin (200mg) supplementation produced a dose-mediated improvement in endothelial function measured by flow-mediated dilation (FMD). The outcome was a clinically substantial 3.0% increase (90% CI 0.7 to 5.3%, ; benefit : harm odds ratio 546:1) with the 200mg dose, relative to placebo. The 50mg dose also increased FMD relative to placebo by 1.7% (-0.6 to 4.0%, ; 25:1), but the outcome was not clinically decisive. In apparently healthy adults, 8 weeks of 200mg oral curcumin supplementation resulted in a clinically meaningful improvement in endothelial function as measured by FMD. Oral curcumin supplementation may present a simple lifestyle strategy for decreasing the risk of cardiovascular diseases. This trial was registered at ISRCTN registry (ISRCTN90184217).
dc.language.isoenen_US
dc.publisherHindawi
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceJournal of Nutrition and Metabolism
dc.subjectflow mediated dilation
dc.subjectNF-kappa B
dc.subjectbrachial artery
dc.subjectvascular health
dc.subjectsports medicine
dc.subjectnitric oxide
dc.subjectdysfunction
dc.subjectantioxidant
dc.subjectactivation
dc.subjectultrasound
dc.titleNovel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study
dc.typeArticle
dc.rights.holder2016 Jonathan M. Oliver et al.
dc.rights.licenseCC BY 4.0
local.collegeHarris College of Nursing and Health Sciences
local.departmentKinesiology
local.personsOliver, Caldwell, S&ers, Kreutzer, Mitchell (KINE)


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