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dc.creatorKalluri, Jhansi R.
dc.creatorWest, Julianna
dc.creatorAkkaraju, Giridhar R.
dc.creatorCanham, Leigh T.
dc.creatorCoffer, Jeffery L.
dc.date.accessioned2019-07-12T16:01:52Z
dc.date.available2019-07-12T16:01:52Z
dc.date.issued2019-05-09
dc.identifier.urihttps://doi.org/10.1021/acsomega.9b00127
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/26411
dc.description.abstractThe properties of nanostructured plant-derived porous silicon (pSi) microparticles as potential candidates to increase the bioavailability of plant extracts possessing anti-inflammatory activity are described in this work. pSi drug carriers were fabricated using an eco-friendly route from the silicon accumulator plant bamboo (tabasheer) powder by magnesiothermic reduction of plant-derived silica and loaded with ethanolic extracts of Equisetum arvense, another silicon accumulator plant rich in polyphenolic compounds. The anti-inflammatory properties of the active therapeutics present in this extract were measured by sensitive luciferase reporter assays; this active extract was subsequently loaded and released from the pSi matrix, with a clear inhibition of the activity of the inflammatory signaling protein NF-KB over a period of hours in a sustained manner. Our results showed that after loading the extracts of E. arvense into pSi microparticles derived from tabasheer, enhanced anti-inflammatory activity was observed owing to enhanced solubility of the extract.en_US
dc.description.statementofresponsibilityKalluri, Coffer (CHEM); West, Akkaraju (BIOL)
dc.publisherAmerican Chemical Society
dc.rights.urihttps://pubs.acs.org/page/policy/authorchoice_termsofuse.html
dc.sourceACS Omega
dc.source.urihttps://pubs.acs.org/doi/10.1021/acsomega.9b00127
dc.subjectMicroparticles
dc.subjectNanoparticles
dc.subjectPorous materials
dc.subjectAntiinflammatories
dc.subjectSilicon
dc.titlePlant-Derived Tandem Drug/Mesoporous Silicon Microcarrier Structures for Anti-Inflammatory Therapy
dc.typeArticleen_US
dc.rights.holderKalluri et al.
dc.rights.licenseThis is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
local.collegeCollege of Science and Engineering
local.departmentChemistry & Biochemistry
local.departmentBiology


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