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dc.creatorKalluri, Jhansi R.
dc.creatorWest, Julianna
dc.creatorAkkaraju, Giridhar R.
dc.creatorCanham, Leigh T.
dc.creatorCoffer, Jeffery L.
dc.date.accessioned2019-07-12T16:01:52Z
dc.date.available2019-07-12T16:01:52Z
dc.date.issued2019-05-09
dc.identifier.urihttps://doi.org/10.1021/acsomega.9b00127
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/26411
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acsomega.9b00127
dc.description.abstractThe properties of nanostructured plant-derived porous silicon (pSi) microparticles as potential candidates to increase the bioavailability of plant extracts possessing anti-inflammatory activity are described in this work. pSi drug carriers were fabricated using an eco-friendly route from the silicon accumulator plant bamboo (tabasheer) powder by magnesiothermic reduction of plant-derived silica and loaded with ethanolic extracts of Equisetum arvense, another silicon accumulator plant rich in polyphenolic compounds. The anti-inflammatory properties of the active therapeutics present in this extract were measured by sensitive luciferase reporter assays; this active extract was subsequently loaded and released from the pSi matrix, with a clear inhibition of the activity of the inflammatory signaling protein NF-KB over a period of hours in a sustained manner. Our results showed that after loading the extracts of E. arvense into pSi microparticles derived from tabasheer, enhanced anti-inflammatory activity was observed owing to enhanced solubility of the extract.
dc.language.isoenen_US
dc.publisherAmerican Chemical Society
dc.rights.urihttps://pubs.acs.org/page/policy/authorchoice_termsofuse.html
dc.sourceACS Omega
dc.subjectMicroparticles
dc.subjectNanoparticles
dc.subjectPorous materials
dc.subjectAntiinflammatories
dc.subjectSilicon
dc.titlePlant-Derived Tandem Drug/Mesoporous Silicon Microcarrier Structures for Anti-Inflammatory Therapy
dc.typeArticle
dc.rights.holderKalluri et al.
dc.rights.licenseThis is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
local.collegeCollege of Science and Engineering
local.departmentChemistry and Biochemistry
local.departmentBiology
local.personsKalluri, Coffer (CHEM); West, Akkaraju (BIOL)


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