The role of exercise in the alleviation of central accumulation of amyloid-beta and prevention of cognitive dysfunction following peripheral inflammation [electronic resource] /Show full item record
|Title||The role of exercise in the alleviation of central accumulation of amyloid-beta and prevention of cognitive dysfunction following peripheral inflammation [electronic resource] /|
|Author||Vinson, Benjamin Tyler|
|Abstract||"Emerging research on neurodegenerative diseases, such as Alzheimer's disease (AD), has tentatively implicated inflammatory processes in the progression of the disease and its clinical manifestations. Previously our lab has explored this link between AD and inflammation. We established a non-transgenic animal model of acute inflammation that produces Aß peptide in a purportedly similar fashion to early sporadic AD, showing that peripheral administration of the endotoxin lipopolysaccharide (LPS), a component of the cell wall of gram-negative bacteria, leads to elevated hippocampal Aß and cognitive deficits. Interestingly, while investigating these peripheral inflammatory connections to AD, data suggested that animals that swam as part of a 9-day behavioral paradigm have reduced hippocampal Aß levels. In the present study we sought to explore the impact of exercise on the cognitive deficits and Aß peptide load seen in our inflammatory model. We hypothesized that voluntary exercise would reduce Aß protein volume in the hippocampus and reduce cognitive impairment after administration of LPS. Our results indicate that mice allowed voluntary exercise (running wheel) for seven days following 7 consecutive days of a single LPS injection displayed reduced hippocampal Aß levels compared to sedentary controls with no differences in behavior between groups"--Abstract.|
|Description||Title from thesis title page (viewed Aug. 25, 2014).
Thesis--Texas Christian University, 2014.
Department of Biology; advisor, Michael J. Chumley.
Includes bibliographical references.
Text (electronic thesis) in PDF.
This item appears in the following Collection(s)
- Theses and Dissertations