Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese WomenShow full item record
Title | Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women |
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Author | Bates, Lauren C.; Hanson, Erik D.; Levitt, Michael M.; Richie, Bryan; Erickson, Elise; Bartlett, David B.; Phillips, Melody D. |
Date | 2021 |
Abstract | (1) Background: Obesity is a major global public health concern as it is associated with many of the leading causes of preventable deaths. Exercise reduces obesity-induced inflammation; however, it is unknown how exercise training may impact mucosal associated invariant T (MAIT) cells in overweight/obese (OW) post-menopausal women. Therefore, the purpose of this study was to investigate (i) circulating MAIT-cells at rest in OW vs. Lean women, (ii) the response of MAIT-cells to a single bout of combined aerobic and resistance exercise, and (iii) the effects of 12 weeks of exercise training (EX) or educational program (ED) on the MAIT-cell response in OW. (2) Methods: OW completed an acute exercise session or sitting control, underwent 12 weeks of exercise training or received educational materials, and then repeated the exercise session/sitting control. Lean post-menopausal women provided a baseline comparison. (3) Results: OW had lower circulating MAIT-cells at rest than Lean prior to exercise training; however, after training EX displayed improved MAIT-cell frequency. Additionally, prior to training EX did not exhibit MAIT-cell mobilization/egress, however, both improved after training. (4) Conclusions: Reduced MAIT-cell frequency and ability to mobilize/egress were potentially partially rescued in EX after 12 weeks of exercise training; however, further research is needed to elucidate age or obesity-induced attenuations in MAIT-cells.</p> |
Link | https://doi.org/10.3390/sports9100133
https://repository.tcu.edu/handle/116099117/49960 |
Department | Kinesiology |
Subject | exercise immunology
aerobic exercise resistance training overweight obesity post-menopausal women mucosal-associated-invariant T-cells |
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- Research Publications [837]
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