Peppermint oil effects on the gut microbiome in children with functional abdominal painShow full item record
|Title||Peppermint oil effects on the gut microbiome in children with functional abdominal pain|
|Author||Thapa S.; Luna R.A.; Chumpitazi B.P.; Oezguen N.; Abdel-Rahman S.M.; Garg U.; Musaad S.; Versalovic J.; Kearns G.L.; Shulman R.J.|
|Abstract||Peppermint oil (PMO) is effective in the treatment of functional abdominal pain disorders, but its mechanism of action is unclear. Evidence suggests PMO has microbicidal activity. We investigated the effect of three different doses of PMO on gut microbiome composition. Thirty children (7–12 years of age) with functional abdominal pain provided a baseline stool sample prior to randomization to 180, 360, or 540 mg of enteric coated PMO (10 participants per dose). They took their respective dose of PMO (180 mg once, 180 mg twice, or 180 mg thrice daily) for 1 week, after which the stool collection was repeated. Baseline and post-PMO stools were analyzed for microbiome composition. There was no difference in alpha diversity of the gut microbiome between the baseline and post-PMO treatment. Principal coordinate analysis revealed no significant difference in overall bacterial composition between baseline and post-PMO samples, as well as between the PMO dose groups. However, the very low abundant Collinsella genus and three operational taxonomic units (one belonging to Collinsella) were significantly different in samples before and after PMO treatment. The Firmicutes/Bacteroidetes ratio was lower in children who received 540 mg of PMO compared to the 180 mg and 360 mg dose groups (p = 0.04). Network analysis revealed separation between pre- and post-PMO fecal samples with the genus Collinsella driving the post-PMO clusters. PMO administration appeared to impact only low abundance bacteria. The 540 mg PMO dose differentially impacted the Firmicutes/Bacteroidetes ratio. A higher dose and/or longer duration of treatment might yield different results. © 2021 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.|
|Department||Burnett School of Medicine|
controlled clinical trial
operational taxonomic unit
principal coordinate analysis
randomized controlled trial
Files in this item
This item appears in the following Collection(s)
- Research Publications 
Showing a few items related by title, author, creator and subject.
Use of Patient Abdominal Compression Device Reduces Staff Musculoskeletal Pain Associated With Supporting Colonoscopy: Results from a Randomized Controlled Trial Crockett, Seth; Dellon, Evan S.; Biggers, Larissa; Ernst, Donna A. (2021)Work-related musculoskeletal disorders occur frequently among the endoscopy staff, and patient-handling duties involved with colonoscopy--applying manual pressure and repositioning patients--are particularly physically ...
Sniffen, Summerlin (2020)Blunt abdominal trauma is one of the most prevalent and fatal injuries presenting in emergency departments (Mofidi et al., 2009). Due to high mortality rates, blunt abdominal trauma generally has a poor prognosis if ...
Parent-child interactions during informal problem-solving: a longitudinal analysis of maternal scaffolding and child development Conner, David Bryan (1992)The importance of parents' contingent instructions during problem-solving interactions has been documented through research in both laboratory and home settings. Using the scaffolding paradigm, this study investigated the ...