dc.creator | Wolf A. | |
dc.creator | Khimani F. | |
dc.creator | Yoon B. | |
dc.creator | Gerhart C. | |
dc.creator | Endsley D. | |
dc.creator | Ray A.K. | |
dc.creator | Yango A.F. | |
dc.creator | Flynn S.D. | |
dc.creator | Lip G.Y.H. | |
dc.creator | Gonzalez S.A. | |
dc.creator | Sathyamoorthy M. | |
dc.date.accessioned | 2022-09-28T17:57:02Z | |
dc.date.available | 2022-09-28T17:57:02Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://doi.org/10.1016/j.tru.2022.100110 | |
dc.identifier.uri | https://repository.tcu.edu/handle/116099117/55824 | |
dc.description.abstract | It is now well established that infection with SARS-CoV-2 resulting in COVID-19 disease includes a severely symptomatic subset of patients in whom an aggressive and/or dysregulated host immune response leads to cytokine storm syndrome (CSS) that may be further complicated by thrombotic events, contributing to the severe morbidity and mortality observed in COVID-19. This review provides a brief overview of cytokine storm in COVID-19, and then presents a mechanistic discussion of how cytokine storm affects integrated pathways in thrombosis involving the endothelium, platelets, the coagulation cascade, eicosanoids, auto-antibody mediated thrombosis, and the fibrinolytic system. © 2022 The Authors | |
dc.language | en | |
dc.publisher | Elsevier | |
dc.rights | 2022 The Authors | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Thrombosis Update | |
dc.subject | Clots | |
dc.subject | Coagulopathy | |
dc.subject | COVID-19 | |
dc.subject | Cytokine storm | |
dc.subject | SARS-CoV2 | |
dc.subject | Thrombosis | |
dc.title | The mechanistic basis linking cytokine storm to thrombosis in COVID-19 | |
dc.type | Review | |
dc.rights.license | CC BY-NC-ND 4.0 | |
local.college | Burnett School of Medicine | |
local.department | Burnett School of Medicine | |
local.persons | All (SOM) | |