|Abstract||The purpose of this research study was three-fold: 1) to determine the relevance of spirituality and faith to females who are homeless, 2) to analyze resilience and hope in the midst of homelessness, and 3) to identify ways assistance agencies can better serve the spiritual needs of homeless persons. Twelve women who were homeless were recruited for the study and interviewed at the Day Resource Center for the Homeless. The researcher gathered quantitative data through a questionnaire and qualitative data through 15 open-ended interview questions. Themes identified during the study included the diverse pathways the participants took into homelessness, the diverse conceptions of spirituality reported by participants, the affirmation that spirituality was relevant to coping with homelessness, and resilience and a positive attitude in the midst of chronic homelessness. A key finding of the study was that basic needs took precedence over spiritual needs for those interviewed. The prevalence of religion and spirituality in the lives of these twelve homeless individuals supports the value of addressing spirituality when conducting assessments and planning interventions among people who are homeless. However, these study findings also reveal that assistance agencies should focus primarily on meeting basic and safety needs before spiritual ones.