Multi-center matched cohort study of convalescent plasma for hospitalized patients with COVID-19Show full item record
Title | Multi-center matched cohort study of convalescent plasma for hospitalized patients with COVID-19 |
---|---|
Author | Zhou, C. K.; Bennett, M. M.; Villa, C. H.; Hammonds, K. P.; Lu, Y.; Ettlinger, J.; Priest, E.L.; Gottlieb, R. L.; Davis, S.; Mays, E.; Clarke, T. C.; Shoaibi, A.; Wong, H.-L.; Anderson, S. A.; Kelly, R. J. |
Date | 2022 |
Abstract | Background Although frequently used in the early pandemic, data on the effectiveness of COVID-19 convalescent plasma (CCP) remain mixed. We investigated the effectiveness and safety of CCP in hospitalized COVID-19 patients in real-world practices during the first two waves of the pandemic in a multi-hospital healthcare system in Texas. Methods and findings Among 11,322 hospitalized patients with confirmed COVID-19 infection from July 1, 2020 to April 15, 2021, we included patients who received CCP and matched them with those who did not receive CCP within ±2 days of the transfusion date across sites within strata of sex, age groups, days and use of dexamethasone from hospital admission to the match date, and oxygen requirements 4-12 hours prior to the match date. Cox proportional hazards model estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for effectiveness outcomes in a propensity score 1:1 matched cohort. Pre-defined safety outcomes were described. We included 1,245 patients each in the CCP treated and untreated groups. Oxygen support was required by 93% of patients at the baseline. The pre-defined primary effectiveness outcome of 28-day in-hospital all-cause mortality (HR = 0.85; 95%CI: 0.66,1.10) were similar between treatment groups. Sensitivity and stratified analyses found similar null results. CCP-treated patients were less likely to be discharged alive (HR = 0.82; 95%CI: 0.74, 0.91), and more likely to receive mechanical ventilation (HR = 1.48; 95%CI: 1.12, 1.96). Safety outcomes were rare and similar between treatment groups. Conclusion The findings in this large, matched cohort of patients hospitalized with COVID-19 and mostly requiring oxygen support at the time of treatment, do not support a clinical benefit in 28-day in-hospital all-cause mortality for CCP. Future studies should assess the potential benefits with specifically high-titer units in perhaps certain subgroups of patients (e.g. those with early disease or immunocompromised). © 2022 Public Library of Science. All rights reserved. |
Link | https://doi.org/10.1371/journal.pone.0273223
https://repository.tcu.edu/handle/116099117/55826 |
Department | Burnett School of Medicine |
Subject | angiotensin receptor antagonist
anticoagulant agent antithrombocytic agent azithromycin chloroquine dexamethasone dipeptidyl carboxypeptidase inhibitor hydrocortisone hydroxychloroquine prednisone remdesivir SARS-CoV-2 convalescent plasma tocilizumab oxygen adult aged all cause mortality Article artificial ventilation clinical outcome cohort analysis confidence interval controlled study convalescent plasma transfusion coronavirus disease 2019 drug safety female gender groups by age hazard ratio health care system hospital admission hospital patient human hypertension in-hospital mortality major clinical study male multicenter study oxygen therapy pandemic proportional hazards model retrospective study sensitivity analysis Texas thromboembolism passive immunization procedures therapy treatment outcome Cohort Studies COVID-19 Humans Immunization, Passive Oxygen SARS-CoV-2 Treatment Outcome |
Files in this item
This item appears in the following Collection(s)
- Research Publications [1008]
Related items
Showing a few items related by title, author, creator and subject.
-
Topographical studies of chick brain synaptic plasma membrane polypeptides
Garadi, Rekha (1977)The topographical distribution of polypeptides of chick synaptic plasma membrane was studied using pyridoxal phosphate and sodium borotritide labeling, lactoperoxidase-catalysed iodination, and neuraminidase and galactose ... -
Association of Hospital Resource Utilization with Neurodevelopmental Outcomes in Neonates with Hypoxic-Ischemic Encephalopathy
Cardona V. Q.; Rao R.; Zaniletti I.; Joe P.; Johnson Y. R.; DiGeronimo R.; Hamrick S. E.; Lee K. -S.; Mietzsch U.; Natarajan G.; Peeples E. S.; Wu T. -W.; Hossain T.; Flibotte J.; Chandel A.; Distler A.; Shenberger J. S.; Oghifobibi O.; Massaro A. N.; Dizon M. L. V. (2023)IMPORTANCE Intercenter variation exists in the management of hypoxic-ischemic encephalopathy (HIE). It is unclear whether increased resource utilization translates into improved neurodevelopmental outcomes. OBJECTIVE To ... -
Trend of Outcome Metrics in Recent Out-of-Hospital-Cardiac-Arrest Research: A Narrative Review of Clinical Trials
Htet, Natalie N.; Jafari, Daniel; Walker, Jennifer A.; Pourmand, Ali; Shaw, Anna; Dinh, Khai; Tran, Quincy K.; Baldi, Enrico; Cortegiani, Andrea (11/20/2023)
© TCU Library 2015 | Contact Special Collections |
HTML Sitemap